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KMID : 0614619940260040716
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Korean Journal of Gastroenterology
1994 Volume.26 No. 4 p.716 ~ p.727
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The Early Changes of Exocrine Pancreas and the Induction of Acute Pacreatitis after Irradiation in Rats
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Abstract
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The first aim of this study was to observe the early changes of exocrine function and morphology after single large dose of irradiation on rat pancreas. In addition, the relationships among irradiated pancreas, hypertrophied pancreas and acute
pancreatitis were investigated. Male Sproague-Dawley rats were used. Single irradiation was given using 1inear accelerator with 6 MeV elecrron beam, dose of 2000 cGy. Acute interstitial pancreatitis was induced by four subcutaneous injections of
caerulein 20㎍/kg at every hour. Camostat 200 mg. Kg(i. g.) was administered for four days to induce pancreatic hypertrophy. The pancreas weight(g/100g B. W.) was increased after irradiation but tissue protein and amylase contents were decreased.
The
pancreatic juice volume were increased at 3 days and 1 week, and then normalized at 3 weeks after irradiation. The pancreatic juice volume, protein and amylase output were decreased in rats with caerulein induced acute pancreatitis. A decrement
of
the
pancreatic juice volume in acute pancreatitis was larger in rats with irradiation than in rats without irradiation. Irradiation worsend the morphologic changes associated with caerulein induced pancreatitis, which were markedly noted at I week
after
irradiation. Camostat induced hypertrophied pancreas exhibited more severe morpologic changes in response tho irradiation combined with caerulein. (Korean J Gastroenterol 1994 ; 26 : 716-727)
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